Zarrindast M R, Moghaddampour E
Department of Pharmacology, Medical Faculty, University of Tehran, Iran.
Arch Int Pharmacodyn Ther. 1991 Jan-Feb;309:42-50.
The effects of dopamine agonists and antagonists on baclofen antinociception were examined in mice using the tail-flick test. Injection of different doses of baclofen (5-10 mg/kg, i.p.) produced dose-related antinociception. This effect was decreased in animals treated with SKF 38393 (8 mg/kg, i.p.) or apomorphine (2 mg/kg, s.c.). The inhibitory responses of both SKF 38393 and apomorphine were decreased in animals pretreated with SCH 23390 (0.1 mg/kg, s.c.). Bromocriptine (1 mg/kg, i.p.), or lower doses of apomorphine (0.1 mg/kg, s.c.), did not alter the baclofen-induced antinociception. Antinociception induced by baclofen (5-10 mg/kg, i.p.) was decreased in animals pretreated with sulpiride (10 mg/kg, i.p.) but not by SCH 23390 (0.1 mg/kg, s.c.). Administration of apomorphine, SKF 38393, bromocriptine or sulpiride alone did not change the latency in the tail-flick test, but SCH 23390 induced a slight but significant antinociception. On the basis of the above findings, it may be concluded that D-1 receptor activation can decrease the baclofen antinociceptive effect.
采用甩尾试验在小鼠中研究了多巴胺激动剂和拮抗剂对巴氯芬镇痛作用的影响。注射不同剂量的巴氯芬（5 - 10毫克/千克，腹腔注射）产生了剂量相关的镇痛作用。在用SKF 38393（8毫克/千克，腹腔注射）或阿扑吗啡（2毫克/千克，皮下注射）处理的动物中，这种作用减弱。在用SCH 23390（0.1毫克/千克，皮下注射）预处理的动物中，SKF 38393和阿扑吗啡的抑制反应均减弱。溴隐亭（1毫克/千克，腹腔注射）或较低剂量的阿扑吗啡（0.1毫克/千克，皮下注射）并未改变巴氯芬诱导的镇痛作用。在用舒必利（10毫克/千克，腹腔注射）预处理的动物中，巴氯芬（5 - 10毫克/千克，腹腔注射）诱导的镇痛作用减弱，但用SCH 23390（0.1毫克/千克，皮下注射）预处理则无此作用。单独给予阿扑吗啡、SKF 38393、溴隐亭或舒必利不会改变甩尾试验中的潜伏期，但SCH 23390可诱导轻微但显著的镇痛作用。基于上述发现，可以得出结论，D - 1受体激活可降低巴氯芬的镇痛作用。
