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底喷流化床包衣机流体动力学的比较研究

Comparative study of the fluid dynamics of bottom spray fluid bed coaters.

作者信息

Chan L W, Tang Elaine S K, Heng Paul W S

机构信息

Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543.

出版信息

AAPS PharmSciTech. 2006 Apr 14;7(2):E37. doi: 10.1208/pt070237.

Abstract

Fluid dynamics of pellets processed in bottom spray traditional Wurster coating and swirl accelerated air (precision) coating were compared with the intent to understand and facilitate improvements in the coating processes. Fluid dynamics was described by pellet mass flow rate (MFR) obtained using a pellet collection system and images captured using high speed photography. Pellet flow within the partition column was found to be denser and slower in Wurster coating than in precision coating, suggesting a higher tendency of agglomeration during the coating process. The influence of partition gap and load on the MFR indicated that the mechanism of transport of pellets into the coating zone in precision coating depended on a strong suction, whereas in Wurster coating, pellets were transported by a combination of peripheral fluidization, gravity, and weak suction pressure. In precision coating, MFR was found to increase uniformly with air flow rate and atomizing pressure, whereas MFR in Wurster coating did not correlate as well with air flow rate and atomizing pressure. This demonstration showed that transport in precision coating was air dominated. In conclusion, fluid dynamics in precision coating was found to be air dominated and dependent on pressure differential, thus it is more responsive to changes in operational variables than Wurster coating.

摘要

对底部喷雾传统Wurster包衣和旋流加速空气(精密)包衣过程中颗粒的流体动力学进行了比较,目的是了解并促进包衣工艺的改进。流体动力学通过使用颗粒收集系统获得的颗粒质量流率(MFR)以及高速摄影拍摄的图像来描述。发现在Wurster包衣中,分隔柱内的颗粒流比精密包衣中更密集、更缓慢,这表明在包衣过程中团聚的倾向更高。分隔间隙和负载对MFR的影响表明,精密包衣中颗粒输送到包衣区的机制取决于强大的吸力,而在Wurster包衣中,颗粒通过周边流化、重力和弱吸力压力的组合进行输送。在精密包衣中,发现MFR随空气流速和雾化压力均匀增加,而Wurster包衣中的MFR与空气流速和雾化压力的相关性则没那么好。这表明精密包衣中的输送以空气为主导。总之,发现精密包衣中的流体动力学以空气为主导且取决于压差,因此它比Wurster包衣对操作变量的变化更敏感。

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