Wang Z L, Grgic B, Finlay W H
Department of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada.
J Aerosol Med. 2006 Summer;19(2):168-74. doi: 10.1089/jam.2006.19.168.
A novel, compact, and highly efficient dry powder inhaler (DPI) with low mouth-throat deposition is described. The performance of this DPI was evaluated by measuring both (1) the total aerosol deposition in and distal to an idealized mouth-throat cast and (2) the fine particle fraction (FPF) using a standard Mark II Anderson impactor. Ultraviolet (UV) spectroscopy techniques were used in the aerosol deposition measurements. Two inhalation aerosol powders, namely budesonide (extracted from a Pulmicort/Turbuhaler multi-dose device, 200 microg/dose) and ciprofloxacin + lipid + lactose (in-house), were dispersed by the DPI at a steady inhalation flow rate of 60 L/min. The newly developed DPI had a total aerosol delivery distal to the mouth-throat cast of 50.5% +/- 3.04% and 69.7% +/- 1.5% for the budesonide and ciprofloxacin + lipid + lactose aerosols, respectively. This is a significant improvement over the Turbuhaler original device delivery of 34.5% +/- 5.2%, particularly considering that in vitro mouth-throat deposition dropped from 27.5% +/- 5.4% with the budesonide Turbuhaler to 11.0% +/- 3.5% with the present inhaler. The different lung deliveries from the same inhaler for the two formulations above also confirm that the overall performance of an inhaler is optimizable via powder formulations.
描述了一种新型、紧凑且高效的干粉吸入器（DPI），其口咽部沉积率较低。通过测量以下两项指标来评估该DPI的性能：（1）理想化口咽部模型及其远端的总气溶胶沉积量；（2）使用标准Mark II安德森撞击器测量细颗粒分数（FPF）。在气溶胶沉积测量中使用了紫外（UV）光谱技术。两种吸入用气溶胶粉末，即布地奈德（从普米克/都保多剂量装置中提取，200微克/剂量）和环丙沙星+脂质+乳糖（自制），由该DPI以60升/分钟的稳定吸入流速进行分散。对于布地奈德和气溶胶以及环丙沙星+脂质+乳糖气溶胶，新开发的DPI在口咽部模型远端的总气溶胶递送率分别为50.5%±3.04%和69.7%±1.5%。这相对于都保原始装置34.5%±5.2%的递送率有显著提高，特别是考虑到体外口咽部沉积率从布地奈德都保的27.5%±5.4%降至本吸入器的11.0%±3.5%。上述两种制剂通过同一吸入器实现的不同肺部递送率也证实，吸入器的整体性能可通过粉末制剂进行优化。
