4%毛果芸香碱凝胶对寻常型天疱疮皮肤损害的治疗作用。
Healing effect of Pilocarpine gel 4% on skin lesions of pemphigus vulgaris.
作者信息
Iraji Fariba, Yoosefi AliReza
机构信息
Department of Dermatology, AL-Zahra Hospital, Isfahan University of Medical Sciences, Iran.
出版信息
Int J Dermatol. 2006 Jun;45(6):743-6. doi: 10.1111/j.1365-4632.2006.02766.x.
BACKGROUND
The high rate of morbidity and mortality resulting from long-term use of corticosteroids in pemphigus vulgaris (PV) warrants discovery of a new treatment strategy. Based on a new theory on the pathophysiology of PV, cholinomimetics can block the process of blister formation.
AIMS
This study was conducted to evaluate the clinical effectiveness of Pilocarpine gel in the treatment of skin lesions of PV.
METHODS
In a double-blind, placebo-controlled study, three PV patients with a total of 64 skin lesions were treated by either Pilocarpine or placebo gel. After 15 days of treatment an epithelialization index of the two groups was compared.
RESULTS
The mean of the epithelialization index in skin lesions that received Pilocarpine was significantly higher than that of the placebo group (40.3 +/- 1.7 vs. 24.4 +/- 3.3, P < 0.001).
CONCLUSIONS
Pilocarpine gel effectively treats PV.
背景
寻常型天疱疮（PV）长期使用皮质类固醇导致的高发病率和死亡率促使人们寻找新的治疗策略。基于PV病理生理学的新理论，拟胆碱药可阻断水疱形成过程。
目的
本研究旨在评估毛果芸香碱凝胶治疗PV皮肤损害的临床疗效。
方法
在一项双盲、安慰剂对照研究中，3例PV患者共64处皮肤损害，分别用毛果芸香碱或安慰剂凝胶治疗。治疗15天后，比较两组的上皮化指数。
结果
接受毛果芸香碱治疗的皮肤损害的上皮化指数平均值显著高于安慰剂组（40.3±1.7对24.4±3.3，P<0.001）。
结论
毛果芸香碱凝胶可有效治疗PV。
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