Braumann Chris, Winkler Goetz, Rogalla Patrick, Menenakos Charalambos, Jacobi Christoph A
Department of General, Visceral, Vascular and Thoracic Surgery, Medical Faculty Charité, Humboldt University, Berlin, Germany.
World J Surg Oncol. 2006 Jun 24;4:34. doi: 10.1186/1477-7819-4-34.
Taurolidine (TRD) is a novel agent with multimodal antineoplastic effects. We present the case of a tumor remission after intravenous administration of taurolidine in a patient with gastric cancer re-recurrence.
A 58 years old male patient suffering from a gastric adenocarcinoma was submitted to partial gastrectomy and partial liver resection (pT2, pN1, pM1L (liver segment 2), N0, V0). 24 months later a local recurrence was diagnosed and the patient was reoperated. Postoperatively the patient underwent a palliative chemotherapy with eloxatin, FU, and leucovorin. A subsequent CT-revealed a liver metastasis and a recurrence adjacent to the hepatic artery. After successful radiofrequency ablation of the liver metastasis the patient was intravenously treated with 2% taurolidine. The patient endured the therapy well and no toxicity was observed. CT-scans revealed a stable disease without a tumor progression or metastatic spread. After 39 cycles the patient was submitted to left nephrectomy due to primary urothelial carcinoma and died 2 days later due to myocardial infarction. Postmortem histology of the esophageal-jejunal anastomosis and liver revealed complete remission of the known metastasized gastric adenocarcinoma.
The intravenous treatment with 2% taurolidine led to a histological remission of the tumor growth without any toxicity for the patient.
牛磺罗定（TRD）是一种具有多模式抗肿瘤作用的新型药物。我们报告了1例胃癌复发患者静脉注射牛磺罗定后肿瘤缓解的病例。
一名58岁男性胃腺癌患者接受了胃部分切除术和肝部分切除术（pT2，pN1，pM1L（肝段2），N0，V0）。24个月后诊断为局部复发，患者再次接受手术。术后患者接受了奥沙利铂、氟尿嘧啶和亚叶酸钙的姑息化疗。随后的CT检查发现肝转移和肝动脉旁复发。在成功进行肝转移灶射频消融后，患者接受了2%牛磺罗定静脉治疗。患者对治疗耐受性良好，未观察到毒性反应。CT扫描显示疾病稳定，无肿瘤进展或转移扩散。39个周期后，患者因原发性尿路上皮癌接受了左肾切除术，2天后因心肌梗死死亡。食管空肠吻合口和肝脏的尸检组织学检查显示已知转移的胃腺癌完全缓解。
2%牛磺罗定静脉治疗导致肿瘤生长组织学缓解，且对患者无任何毒性。
