Zhang Yu-shi, Li Han-zhong, Zhang Rui-qiang, Shi Bing-bing
Department of Urology, Peking Union Medical College Hospital, Peking Medical College, Beijing 1200730, China.
Zhonghua Yi Xue Za Zhi. 2006 May 23;86(19):1305-8.
To investigate the characteristics of recurrence of T1G3 transitional cell carcinoma (TCC) of bladder.
The clinical data of 72 patients with TCC of bladder of the stage T1, 37 being of the stage T1G3 and 35 being of the stage T1G1-2, who underwent the initial treatment by transurethral resection of bladder tumor plus post-operative bladder infusion were analyzed.
The first, second, third, and fourth year recurrent rates of the T1G3 group were 29.7%, 40.5%, 18.9%, and 10.8% respectively, all significantly higher than those of the T1G2 group (14.3%, 34.3%, 31.4%, and 20.0% respectively, t = 1.994, P = 0.025). The rate of recurrence for only time was 10.8% in the T1G3 group (4/37), significantly lower than that of the T1G1-2 group (17/35, 48.6%, P < 0.01). The rate of recurrence for more than 3 times was 54.0% in the T1G3 group (20/37), significantly higher than that of the T1G1-2 group (6/35, 17.2%, P < 0.01). The rate of recurrent tumor at the pathological stage over T2 was 86.5% (32/37) in the T1G3 group, higher than that of the T1G1-2 group (42.8%, 15/35). The rate of partial or total cystectomy at the last recurrence in the T1G3 group was 94.6% (35/37), significantly higher than that of the T1G1-2 group (57.1%, 20/35, chi(2) = 14.00, P < 0.05).
A kind of dangerous bladder cancer, TCC at the stage T1G3 is apt recur soon after the treatment with a high recurrent frequency. Most recurrent tumors evolve into invasive cancer.
探讨膀胱T1G3移行细胞癌（TCC）的复发特点。
分析72例T1期膀胱TCC患者的临床资料，其中37例为T1G3期，35例为T1G1 - 2期，均接受经尿道膀胱肿瘤切除术及术后膀胱灌注初始治疗。
T1G3组第1、2、3、4年的复发率分别为29.7%、40.5%、18.9%和10.8%，均显著高于T1G2组（分别为14.3%、34.3%、31.4%和20.0%，t = 1.994，P = 0.025）。T1G3组仅复发1次的比例为10.8%（4/37），显著低于T1G1 - 2组（17/35，48.6%，P < 0.01）。T1G3组复发3次以上的比例为54.0%（20/37），显著高于T1G1 - 2组（6/35，17.2%，P < 0.01）。T1G3组病理分期超过T2期的复发肿瘤比例为86.5%（32/37），高于T1G1 - 2组（42.8%，15/35）。T1G3组末次复发时行部分或全膀胱切除术的比例为94.6%（35/37），显著高于T1G1 - 2组（57.1%，20/35，χ(2)=14.00，P < 0.05）。
T1G3期TCC是一种危险的膀胱癌，治疗后易早期复发且复发频率高。大多数复发肿瘤会进展为浸润性癌。
