Mikkelsen Jens D, Larsen Marianne H
Department of Functional Neuroanatomy and Biomarkers, Neurosearch A/S, Pederstrupvej 93, 2750 Ballerup, Denmark.
Neurosci Lett. 2006 Aug 7;403(3):239-43. doi: 10.1016/j.neulet.2006.04.040. Epub 2006 Jun 21.
Activity-regulated cytoskeletal-associated protein (Arc) is an effector immediate early gene induced by novelty and involved in consolidation of long-term memory. Since activation of glucocorticoid receptors is a prerequisite for memory consolidation, we therefore aimed to study the effect of acute restraint stress on Arc gene expression in adrenalectomized rats. Acute stress produced a significant increase in Arc gene expression in the medial prefrontal cortex, but not in the parietal cortex or in the pyramidal cell layer of the hippocampus. The basal level of Arc mRNA in adrenalectomized animals was high in the medial prefrontal cortex and unaffected by acute stress in these animals. These data are consistent with the role of Arc as an integrative modulator of synaptic plasticity by emphasizing the potential role of stress and glucocorticoids in the control of Arc gene expression.
活性调节细胞骨架相关蛋白（Arc）是一种由新奇事物诱导的效应即刻早期基因，参与长期记忆的巩固。由于糖皮质激素受体的激活是记忆巩固的先决条件，因此我们旨在研究急性束缚应激对肾上腺切除大鼠Arc基因表达的影响。急性应激使内侧前额叶皮质中的Arc基因表达显著增加，但顶叶皮质或海马锥体细胞层中未出现这种情况。肾上腺切除动物中Arc mRNA的基础水平在内侧前额叶皮质中较高，且不受急性应激的影响。这些数据通过强调应激和糖皮质激素在控制Arc基因表达中的潜在作用，与Arc作为突触可塑性整合调节剂的作用相一致。
