Zeybek U, Isbir T, Ergen H A, Yilmaz H, Hekim N, Akoglu E
University of Istanbul, Institute of Experimental Medicine, Research Department of Molecular Medicine, Istanbul, Turkey.
Transplant Proc. 2006 Jun;38(5):1382-4. doi: 10.1016/j.transproceed.2006.03.039.
Dyslipidemia is an important complication in renal transplant patients. Cholesteryl ester transfer protein (CETP) mediates the exchange of cholesteryl ester between high density lipoproteins and low density lipoproteins. The aim of this study was to investigate CETP Taq1B gene polymorphism and lipid abnormalities in renal transplant patients.
We studied 29 renal transplant patients and 29 healthy controls. CETP Taq1B polymorphism was determined by polymerase chain reaction and restriction fragment length polymorphism techniques. Serum lipid levels were measured enzymatically. Statistical analyses was performed by SPSS for Windows version 7.5.
The frequencies of CETP Taq1B B1B1, B1B2, and B2B2 genotypes in patients were 44.8%, 34.5%, and 20.7%; and in control subjects, 37.9%, 37.9%, and 24.2%, respectively. The patients with B1B1 genotype displayed higher levels of total cholesterol (TC), triglycerides, low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C), and diastolic blood pressure (DBP). (P<.05). Also, patients showing a B1 allele had higher levels of TC, LDL-C, VLDL-C, and DBP compared to healthy controls (P<.05).
We observed that CETP Taq1B B1 allele and B1B1 genotype have effects on the serum lipid profile among renal transplant patients.
血脂异常是肾移植患者的重要并发症。胆固醇酯转运蛋白（CETP）介导高密度脂蛋白与低密度脂蛋白之间胆固醇酯的交换。本研究旨在探讨肾移植患者中CETP Taq1B基因多态性与脂质异常情况。
我们研究了29例肾移植患者和29名健康对照者。通过聚合酶链反应和限制性片段长度多态性技术确定CETP Taq1B基因多态性。采用酶法测定血清脂质水平。使用SPSS for Windows 7.5版进行统计分析。
患者中CETP Taq1B B1B1、B1B2和B2B2基因型的频率分别为44.8%、34.5%和20.7%；对照者中分别为37.9%、37.9%和24.2%。B1B1基因型患者的总胆固醇（TC）、甘油三酯、低密度脂蛋白胆固醇（LDL-C）、极低密度脂蛋白胆固醇（VLDL-C）和舒张压（DBP）水平较高（P<0.05）。此外，与健康对照者相比，携带B1等位基因的患者TC、LDL-C、VLDL-C和DBP水平较高（P<0.05）。
我们观察到CETP Taq1B B1等位基因和B1B1基因型对肾移植患者的血清脂质谱有影响。
