硝酸甲基阿托品增加大鼠肠肌层而非迷走背核复合体中Fos样免疫反应性。
Atropine methyl nitrate increases myenteric but not dorsal vagal complex Fos-like immunoreactivity in the rat.
作者信息
Raboin Shannon J, Gulley Stephen, Henley Sheryce C, Chan Wai-Chu, Esdaile Alton R, Sayegh Ayman I
机构信息
Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, AL 36088, USA.
出版信息
Physiol Behav. 2006 Jul 30;88(4-5):448-52. doi: 10.1016/j.physbeh.2006.04.015. Epub 2006 Jun 22.
Atropine methyl nitrate (AMN, 0.05, 0.5 and 25 mg/kg) intraperitoneally increased Fos-like immunoreactivity (Fos-LI) in the myenteric plexus, but not the dorsal vagal complex (DVC, the area postrema (AP), nucleus of the solitary tract (NTS) and the dorsal motor nucleus of the vagus (DMV)) in adult, male Sprague-Dawley rats. A 3 mg/kg AMN dose decreased intake of 15% sucrose, but failed to increase Fos-LI in both locations. In conclusion, the myenteric plexus may play a local role in the behavioral response evoked by AMN.
腹腔注射硝酸甲基阿托品（AMN，剂量为0.05、0.5和25毫克/千克）可增加成年雄性Sprague-Dawley大鼠肌间神经丛中Fos样免疫反应性（Fos-LI），但不会增加迷走背核复合体（DVC，包括最后区（AP）、孤束核（NTS）和迷走神经背运动核（DMV））中的Fos-LI。3毫克/千克的AMN剂量可减少15%蔗糖的摄入量，但未能增加这两个部位的Fos-LI。总之，肌间神经丛可能在AMN诱发的行为反应中发挥局部作用。
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