转录与修复相遇时：一个复杂的系统。
When transcription and repair meet: a complex system.
作者信息
Lainé Jean-Philippe, Egly Jean-Marc
机构信息
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, BP 163, 67404 Illkirch Cedex, C. U. Strasbourg, France.
出版信息
Trends Genet. 2006 Aug;22(8):430-6. doi: 10.1016/j.tig.2006.06.006. Epub 2006 Jun 23.
Transcription-coupled repair (TCR) is a mechanism that removes DNA lesions so that genes can be transcribed correctly. However, the sequence of events that results in a DNA lesion being repaired remains elusive. In this review, we illustrate the potential chain of events leading to the elimination of the damaged DNA and the proper resumption of transcription. We focus on the roles of CSA and CSB proteins, which, when mutated, impair TCR. Defective TCR is one of the features of Cockayne syndrome, a DNA-repair disorder.
转录偶联修复（TCR）是一种去除DNA损伤从而使基因能够正确转录的机制。然而，导致DNA损伤得以修复的一系列事件顺序仍不清楚。在这篇综述中，我们阐述了导致受损DNA被清除以及转录得以正常恢复的潜在事件链。我们重点关注CSA和CSB蛋白的作用，当这两种蛋白发生突变时会损害转录偶联修复。有缺陷的转录偶联修复是科凯恩综合征（一种DNA修复障碍疾病）的特征之一。
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