一系列1β-甲基碳青霉烯衍生物的合成及其体外活性
Synthesis and in vitro activity of a series 1beta-methylcarbapenem derivatives.
作者信息
Jeon H C, Kim J-W, Hong J H, Cho J-H, Oh C-H
机构信息
Department of Chemistry, Hanyang University, Seoul, Korea.
出版信息
Eur J Med Chem. 2006 Oct;41(10):1201-9. doi: 10.1016/j.ejmech.2006.05.003. Epub 2006 Jun 22.
PMID:16797791
Abstract
The synthesis of a new series of 1beta-methylcarbapenems having pyrrolidine and piperidine moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. A particular compound (IIIb) having hydroxypyrrolidine moiety showed the most potent antibacterial activity.
摘要
描述了一系列具有吡咯烷和哌啶部分的新型1β-甲基碳青霉烯的合成。测试了它们对革兰氏阳性菌和革兰氏阴性菌的体外抗菌活性，并研究了取代基对吡咯烷环的影响。一种具有羟基吡咯烷部分的特定化合物（IIIb）表现出最强的抗菌活性。
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