Shanson D C
Department of Medical Microbiology, Charing Cross and Westminster Medical School, London, UK.
J Hosp Infect. 1991 Jun;18 Suppl A:170-6. doi: 10.1016/0195-6701(91)90020-9.
There are increasingly strong arguments for the introduction of wider screening of all kinds of patients, including surgical patients, to diagnose otherwise undetected human immunodeficiency virus (HIV) infection in order to facilitate earlier treatment of HIV infection with zidovudine. Wider screening may also help to limit the spread of HIV in the community as infected patients may be counselled and more effective public health measures planned. In areas of high prevalence voluntary universal screening test programmes should be encouraged whereas in areas of low to medium prevalence more selective screening tests would be appropriate on people belonging to risk groups. Screening of patients undergoing elective surgery for infection control purposes is most appropriate in areas of low to medium prevalence so that extra precautions in the operating theatre can be selected for those patients who are screened and deemed to be at high risk. Screening methods include taking a comprehensive clinical history to include specific questions about risk group behaviour, questionnaire methods, serological screening tests and a combination of these three types of approach. Screening HIV antibody tests are recommended, with informed consent, of those patients who belong to risk groups. A further benefit of screening for infection control purposes occurs in the event of a sharps injury when prior testing of the source patient helps to facilitate decision making about the giving of immediate zidovudine prophylaxis.
对于对包括外科手术患者在内的各类患者进行更广泛筛查以诊断出原本未被发现的人类免疫缺陷病毒(HIV)感染,从而促进尽早使用齐多夫定治疗HIV感染,现在有越来越有力的论据。更广泛的筛查还可能有助于限制HIV在社区中的传播,因为可以为感染患者提供咨询,并规划更有效的公共卫生措施。在高流行地区,应鼓励开展自愿普遍筛查检测项目,而在中低流行地区,对属于高危人群的人进行更有选择性的筛查检测则更为合适。出于感染控制目的,对接受择期手术的患者进行筛查在中低流行地区最为合适,这样可以为那些经筛查被认定为高危的患者在手术室采取额外的预防措施。筛查方法包括全面的临床病史询问,包括关于高危人群行为的具体问题、问卷调查方法、血清学筛查检测以及这三种方法的组合。建议在获得知情同意的情况下,对属于高危人群的患者进行HIV抗体检测。出于感染控制目的进行筛查的另一个好处是,在发生锐器伤时,对源患者进行预先检测有助于促进关于立即给予齐多夫定预防用药的决策。