气道廓清的药理学方法：黏液促排剂。

The pharmacologic approach to airway clearance: mucoactive agents.

作者信息

Rubin Bruce K

机构信息

Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157-1081, USA.

出版信息

Paediatr Respir Rev. 2006;7 Suppl 1:S215-9. doi: 10.1016/j.prrv.2006.04.198. Epub 2006 Jun 5.

DOI:10.1016/j.prrv.2006.04.198

PMID:16798570

Abstract

The term "mucoactive agent" refers to any medication used to improve the clearance of airway secretions. It is not synonymous with the word "mucolytic" as this strictly means a drug that decreases the viscosity of secretions. In many cases, decreased viscosity will adversely affect cough transport. For this reason many of the older mucolytic agents such as acetylcysteine are not effective for the therapy of lung disease and their use is not recommended. I review here the many classes of mucoactive agents and identify a number of medications with great promise for the treatment of chronic airway disease.

摘要

“黏液促排剂”一词指的是用于改善气道分泌物清除的任何药物。它与“黏液溶解剂”并非同义词，因为后者严格来说是指一种能降低分泌物黏稠度的药物。在许多情况下，黏稠度降低会对咳嗽排痰产生不利影响。因此，许多较老的黏液溶解剂，如乙酰半胱氨酸，对肺部疾病治疗无效，不建议使用。在此，我将回顾黏液促排剂的多个类别，并确定一些对慢性气道疾病治疗极具前景的药物。