1998年至2004年加拿大新增丙型肝炎病毒感染的强化监测

Enhanced surveillance of newly acquired hepatitis C virus infection in Canada, 1998 to 2004.

作者信息

Wu Hong-Xing, Wu Jun, Wong Tom, Donaldson Tracey, Dinner Katherine, Andonov Anton, Ip Chan Jessica, Moffat Barbara, Baptiste Beverley, Furseth Janet, Poliquin Darlene, Bolesnikov Grlica, Giulivi Antonio, Paton Shirley

机构信息

Blood Safety Surveillance and Health Care Acquired Infection Division, Centre for Infectious Disease Prevention and Control, Public Health Agency of Canada, Ottawa, ON.

出版信息

Scand J Infect Dis. 2006;38(6-7):482-9. doi: 10.1080/00365540500525161.

DOI:10.1080/00365540500525161

PMID:16798699

Abstract

The purpose of this study was to determine trends in disease incidence and recent patterns of hepatitis C virus (HCV) transmission in Canada, using the Enhanced Hepatitis Strain Surveillance System (EHSSS). Demographic, clinical, and potential risk factor information on newly acquired HCV infection, from 1998 to 2004, was collected using standardized questionnaires. During this time period, the reported incidence of newly acquired HCV infection declined by 36.4% from 3.3 cases per 100,000 in 1998, to 2.1 cases per 100,000 in 2004. The disease incidence peaked at 15 to 39 y of age, confirming injecting drug use as the most frequently reported route of transmission. The proportion of cases attributed to health care-acquired HCV infection decreased over this time period. Although the incidence of newly acquired HCV infection in the EHSSS was found to be declining, hepatitis C remains an important public health threat to Canadians. Prevention efforts for HCV should focus on injection drug use, especially for people aged 15 to 39 y.

摘要

本研究的目的是利用强化型丙肝病毒株监测系统（EHSSS）来确定加拿大疾病发病率的趋势以及丙型肝炎病毒（HCV）近期的传播模式。1998年至2004年期间，通过标准化问卷收集了新感染HCV患者的人口统计学、临床和潜在风险因素信息。在此期间，新感染HCV的报告发病率从1998年的每10万人3.3例下降了36.4%，降至2004年的每10万人2.1例。发病率在15至39岁达到峰值，证实注射吸毒是最常报告的传播途径。在此期间，归因于医疗保健获得性HCV感染的病例比例有所下降。尽管在EHSSS中发现新感染HCV的发病率在下降，但丙型肝炎仍然是加拿大人面临的重要公共卫生威胁。HCV的预防工作应侧重于注射吸毒，尤其是针对15至39岁的人群。