Nishiyama Yasuhiro, Minohara Motooki, Ohe Masatugu, Hirai Yuji, Katoh Atsushi, Miyamoto Tetsuya, Iwami Gensyo, Nakata Masashi, Koga Yoshinori
Division of Cardiology, Kurume University Medical Center, Kurume, Japan.
Circ J. 2006 Jul;70(7):864-7. doi: 10.1253/circj.70.864.
The effect of physical training on insulin resistance (IR) in chronic heart failure (CHF) remains unclear.
Fourteen patients with CHF performed physical training using a bicycle ergometer; 9 patients (64%) were hyperinsulinemic and insulin resistant (HOMA IR > 1.97). Exercise tolerance increased (5.1 +/- 1.7 to 6.9 +/- 2.7 METs, p < 0.05) and heart rate at rest decreased (82 +/- 15 to 72 +/- 6, p < 0.05) in the IR group after physical training. Physical training also decreased the insulin level (15.1 +/- 5.6 to 9.8 +/- 2.6 microU/ml, p < 0.05) and HOMA IR (3.7 +/- 1.4 to 2.3 +/- 0.6, p < 0.05) in the IR group, but not in the 5 patients (36%) without IR or in 6 control patients.
Physical training can improve hyperinsulinemia and IR in patients with CHF.
体育锻炼对慢性心力衰竭（CHF）患者胰岛素抵抗（IR）的影响尚不清楚。
14例CHF患者使用自行车测力计进行体育锻炼；9例患者（64%）存在高胰岛素血症且胰岛素抵抗（稳态模型评估胰岛素抵抗指数>1.97）。体育锻炼后，IR组的运动耐量增加（从5.1±1.7代谢当量增加到6.9±2.7代谢当量，p<0.05），静息心率降低（从82±15次/分钟降至72±6次/分钟，p<0.05）。体育锻炼还降低了IR组的胰岛素水平（从15.1±5.6微单位/毫升降至9.8±2.6微单位/毫升，p<0.05）和稳态模型评估胰岛素抵抗指数（从3.7±1.4降至2.3±0.6，p<0.05），但对5例无IR的患者（36%）和6例对照患者没有影响。
体育锻炼可改善CHF患者的高胰岛素血症和胰岛素抵抗。
