Hasegawa Hiroshi, Takano Hiroyuki, Shiraishi Hirokazu, Ueda Kazutaka, Niitsuma Yuriko, Tadokoro Hiroyuki, Komuro Issei
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
Circ J. 2006 Jul;70(7):942-4. doi: 10.1253/circj.70.942.
Although granulocyte colony-stimulating factor (G-CSF) is known to prevent left ventricular (LV) remodeling after acute myocardial infarction (AMI), the best method of administration is unknown.
A rabbit ischemia/reperfusion model was created and G-CSF was administered into the coronary artery immediately after reperfusion. The LV size and contraction were determined by echocardiography, and the extent of infarcted myocardium was measured by Masson-Trichrome staining. The benefits of intracoronary injection of G-CSF on LV remodeling were similar to subcutaneous injection.
Direct intracoronary G-CSF injection may become a new therapy for AMI with lower adverse effects.
