激肽释放酶相关肽酶（KLK）家族mRNA变体和蛋白质异构体在激素相关癌症中的作用：它们有功能吗？
Kallikrein-related peptidase (KLK) family mRNA variants and protein isoforms in hormone-related cancers: do they have a function?
作者信息
Tan Olivia L, Whitbread Astrid K, Clements Judith A, Dong Ying
机构信息
Hormone-Dependent Cancer Research Program, School of Life Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane 4001, QLD, Australia.
出版信息
Biol Chem. 2006 Jun;387(6):697-705. doi: 10.1515/BC.2006.088.
The kallikrein-related peptidase (KLK) gene family of 15 serine proteases encodes many proteins, including prostate specific antigen (PSA or KLK3), that are well described and/or are potential biomarkers for hormone-related cancers. Variant mRNA transcripts produced by alternative splicing, polyadenylation or AUG sites, or intron retention have been found for each of the KLK genes. The predicted protein for many of these alternative transcripts is different from that of the classical kallikrein-related peptidases and would not be an active serine protease. The majority of these novel protein isoforms have not been studied in vivo. The possible function(s) of the variant transcripts/protein isoforms and potential roles that they may play in hormone-related cancers are still unknown and are the focus of this short review.
由15种丝氨酸蛋白酶组成的激肽释放酶相关肽酶（KLK）基因家族编码许多蛋白质，包括前列腺特异性抗原（PSA或KLK3），这些蛋白质已有充分描述和/或可能是激素相关癌症的生物标志物。已在每个KLK基因中发现了由可变剪接、聚腺苷酸化或AUG位点或内含子保留产生的可变mRNA转录本。许多这些可变转录本预测的蛋白质与经典激肽释放酶相关肽酶不同，不会是活性丝氨酸蛋白酶。这些新型蛋白质异构体中的大多数尚未在体内进行研究。可变转录本/蛋白质异构体的可能功能以及它们在激素相关癌症中可能发挥的潜在作用仍然未知，是本简短综述的重点。
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