Ayhan A, Yapar E G, Yüce K, Kişnişci H A, Nazli N, Ozmen F
Department of Obstetrics and Gynecology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Int J Gynaecol Obstet. 1991 Jun;35(2):117-22. doi: 10.1016/0020-7292(91)90813-k.
The outcome of 64 pregnancies in 40 women who conceived after cardiac valve replacement were reviewed. Fetal wastage was 53.2% (25/47) in coumarin administered pregnancies, 36.4% (4/11) using heparin and 16.7% (1/6) without anticoagulants. Two fetal malformations were noted in coumarin administered pregnancies. There were two maternal deaths. Maternal morbidity due to antenatal bleeding, atrial fibrillation, thromboembolic episodes and cardiac failure were found to be 20.0% (8/40), 17.5% (7/40), 10.0% (4/40) and 10.0% (4/40), respectively.
对40名在心脏瓣膜置换术后怀孕的女性的64次妊娠结局进行了回顾。接受香豆素治疗的妊娠中胎儿丢失率为53.2%（25/47），使用肝素的为36.4%（4/11），未使用抗凝剂的为16.7%（1/6）。接受香豆素治疗的妊娠中有两例胎儿畸形。有两例孕产妇死亡。产前出血、房颤、血栓栓塞事件和心力衰竭导致的孕产妇发病率分别为20.0%（8/40）、17.5%（7/40）、10.0%（4/40）和10.0%（4/40）。
