Chang M S, Ho B C, Chan K L
Medical Department, Jalan Tun Abang Hj. Openg, Kuching, Sarawak, Malaysia.
Trop Med Parasitol. 1991 Jun;42(2):95-102.
A control programme against subperiodic brugian filariasis was implemented in three villages, (Kg. Ampungan, Kg. Sebangkoi and Kg. Sebamban) in Sarawak, Malaysia. In Kampong Ampungan, the mass administration of diethylcarbamazine (DEC-citrate) combined with residual house spraying of pirimiphos-methyl reduced microfilarial rate to 8% of the pre-treatment level and microfilarial density (MfD50) to 44% of the pre-treatment level over a period of four years. In Kampong Sebangkoi and Kampong Sebamban, where only mass DEC therapy was applied, the microfilarial rate and MfD50 declined distinctly in the second blood survey but increased gradually in two subsequent follow-up blood surveys. In Kg, Ampungan, we observed a significant reduction of infective biting rate (88.3%), infection rate (62.5%) and transmission potential (88.1%) of Mansonia bonneae at the fourth spray round. The corresponding reduction rates in Kg. Sebangkoi and Kg. Sebamban were 35.3%, 26.7%, 42.2% and 24%, 30.8% and 15.4% respectively. The biting density of the vector was reduced by 79.8% indoors and 31.8% outdoors at the sprayed village, while only a slight decrease in densities (17.9% indoors and 12.4% outdoors) was observed at the unsprayed village. Bioassay tests revealed that pirimiphos-methyl had a substantial fumigant effect on the vector. The integrated control measure in controlling subperiodic brugian filariasis is discussed.
在马来西亚砂拉越的三个村庄（Kg. Ampungan、Kg. Sebangkoi和Kg. Sebamban）实施了一项针对亚周期型布鲁氏丝虫病的控制计划。在甘榜安蓬，乙胺嗪（枸橼酸乙胺嗪）的群体给药与甲基嘧啶磷的室内滞留喷洒相结合，在四年时间内将微丝蚴率降至治疗前水平的8%，微丝蚴密度（MfD50）降至治疗前水平的44%。在甘榜塞邦科伊和甘榜塞班班，仅采用了乙胺嗪群体治疗，在第二次血液调查中微丝蚴率和MfD50明显下降，但在随后的两次随访血液调查中逐渐上升。在Kg. Ampungan，在第四次喷洒轮次时，我们观察到曼氏蚊的感染叮咬率（88.3%）、感染率（62.5%）和传播潜能（88.1%）显著降低。Kg. Sebangkoi和Kg. Sebamban的相应降低率分别为35.3%、26.7%、42.2%和24%、30.8%、15.4%。在喷洒过的村庄，媒介的叮咬密度在室内降低了79.8%，在室外降低了31.8%，而在未喷洒的村庄，仅观察到密度略有下降（室内17.9%，室外12.4%）。生物测定试验表明，甲基嘧啶磷对该媒介有显著的熏蒸作用。文中讨论了控制亚周期型布鲁氏丝虫病的综合控制措施。
