Jansson J R, Fukada T, Ozaki M, Kimura S
Medical Neuroscience, AstraZeneca R&D, Sodertalje, Sweden.
Anaesth Intensive Care. 2006 Jun;34(3):362-8. doi: 10.1177/0310057X0603400305.
Propofol formulated in a lipid vehicle supports the growth of microorganisms. There have been worldwide reports of extrinsic microbial contamination of propofol leading to outbreaks of serious postoperative nosocomial infections. Therefore it is essential that medical professionals follow strict aseptic precautions when handling propofol, as recommended by manufacturers of propofol and the Centers for Disease Control and Prevention. Non-adherence to these recommendations increases the risk of nosocomial postoperative infections, which impose a heavy burden of morbidity and mortality and have serious economic consequences. It has also been recommended that the use of EDTA-containing formulations of propofol be considered. In vitro studies have confirmed that EDTA added to propofol retards microbial growth. Data on the incidence of nosocomial infections before and after the introduction of propofol with EDTA indicates that there have been no further cluster outbreaks and individual nosocomial infections appear to have been reduced. The addition of EDTA is an additional safety precaution to good aseptic practice.
以脂质载体配制的丙泊酚可支持微生物生长。全球范围内均有关于丙泊酚受到外在微生物污染导致严重术后医院感染暴发的报道。因此，医疗专业人员在处理丙泊酚时必须遵循制造商以及疾病控制与预防中心所建议的严格无菌预防措施。不遵守这些建议会增加术后医院感染的风险，此类感染会带来沉重的发病和死亡负担，并产生严重的经济后果。也有人建议考虑使用含乙二胺四乙酸（EDTA）的丙泊酚制剂。体外研究已证实，向丙泊酚中添加EDTA可延缓微生物生长。有关引入含EDTA丙泊酚前后医院感染发生率的数据表明，此后未再出现聚集性暴发，且个别医院感染似乎有所减少。添加EDTA是良好无菌操作之外的一项额外安全预防措施。
