Nowak J Z, Sek B
Department of Biogenic Amines, Polish Academy of Sciences, Lodz.
Agents Actions. 1991 May;33(1-2):138-42. doi: 10.1007/BF01993149.
Histamine (HA), 1-1000 microM, significantly stimulated both basal and forskolin-activated cAMP generation in chicken and adult hen retina. The action of HA was reproduced by the selective H2-receptor agonists dimaprit and 4-methyl-histamine, but not by the selective H1-receptor agonist 2-thiazolylethylamine, and it was antagonized by the specific H2-receptor blockers cimetidine and tiotidine, but not by the H1-receptor blocker mepyramine. In parallel experiments, dopamine, an established retinal neuromodulator acting through the D1-type of receptor, also stimulated basal and forskolin-driven adenylate cyclase activity in homogenate of chicken retina. It is suggested that chicken retina contains HA H2-receptors which are positively coupled to the adenylate cyclase system.
组胺（HA），浓度为1 - 1000微摩尔，显著刺激了鸡和成年母鸡视网膜中的基础cAMP生成以及福斯高林激活的cAMP生成。HA的作用可被选择性H2受体激动剂二甲双胍和4 - 甲基组胺重现，但不能被选择性H1受体激动剂2 - 噻唑基乙胺重现，且它被特异性H2受体阻滞剂西咪替丁和替丁拮抗，但不被H1受体阻滞剂美吡拉敏拮抗。在平行实验中，多巴胺作为一种通过D1型受体起作用的视网膜神经调节剂，也刺激了鸡视网膜匀浆中的基础和福斯高林驱动的腺苷酸环化酶活性。提示鸡视网膜含有与腺苷酸环化酶系统正性偶联的HA H2受体。
