Linnestad P, Guldvog I, Schrumpf E
Scand J Gastroenterol. 1983 Mar;18(2):165-8. doi: 10.3109/00365528309181578.
The influence of histamine, H1 and H2 agonists (2-AETD and dimaprit), and H1 and H2 antagonists (mepyramine and cimetidine) on the postprandial release of pancreatic polypeptide (PP) was assessed in five Labrador retrievers. Infusions of histamine, 0.25 mumol kg-1 h-1; 2AETD, 4 mumol kg-1 h-1; and dimaprit, 1 mumol kg-1 h-1, enhanced postprandial release (131-189% of control values). The response to 2-AETD and dimaprit was significantly different from control values (p less than 0.05). An increase was observed even when 50 mg mepyramine and 400 mg cimetidine were injected as intravenous boluses (131-139% of control values (p less than 0.05]. The action of the antagonists may be explained by partial agonism or histamine release induced by these agents. It is concluded that postprandial PP release is stimulated by H1 and H2 receptors.
在五只拉布拉多猎犬中评估了组胺、H1和H2激动剂（2-氨基乙硫醇和二甲双胍）以及H1和H2拮抗剂（美吡拉敏和西咪替丁）对餐后胰多肽（PP）释放的影响。输注组胺，0.25μmol kg-1 h-1；2-氨基乙硫醇，4μmol kg-1 h-1；以及二甲双胍，1μmol kg-1 h-1，可增强餐后释放（为对照值的131-189%）。对2-氨基乙硫醇和二甲双胍的反应与对照值有显著差异（p<0.05）。即使静脉推注50mg美吡拉敏和400mg西咪替丁，也观察到增加（为对照值的131-139%（p<0.05））。拮抗剂的作用可能由这些药物诱导的部分激动作用或组胺释放来解释。结论是餐后PP释放受H1和H2受体刺激。
