Ostomel Todd A, Shi Qihui, Stucky Galen D
Department of Chemistry and Biochemistry, University of California-Santa Barbara, Santa Barbara, CA 93106, USA.
J Am Chem Soc. 2006 Jul 5;128(26):8384-5. doi: 10.1021/ja061717a.
The tunable in vitro blood clotting activity of high-surface-area hemostatic bioactive glass is evaluated by Thromboelastograph, a clinical instrument for quantifying changes in blood during coagulation. The hemostatic trends associated with hemostatic bioactive glass and a new preparation of spherical hemostatic bioactive glass, along with similar Si- and Ca-containing oxides, are described and related to Si:Ca ratios, Ca2+ availability and coordination environment, porosity, DeltaHHydration, and surface area. Hemostatic bioactive glass is a new material with an excellent efficacy for inducing hemostasis and is chemically distinct from the traditional bioglass employed for bone growth.
通过血栓弹力图仪（一种用于量化凝血过程中血液变化的临床仪器）评估了高表面积止血生物活性玻璃的体外可调凝血活性。描述了与止血生物活性玻璃以及新型球形止血生物活性玻璃制剂相关的止血趋势，以及类似的含硅和钙的氧化物，并将其与硅钙比、钙离子可用性和配位环境、孔隙率、水化热变以及表面积联系起来。止血生物活性玻璃是一种诱导止血效果极佳的新型材料，在化学组成上与用于骨生长的传统生物玻璃不同。
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