Günther E, Kiesel U, Kolb H, Krawczak M, Rothermel E, Wurst W
Abteilung Immungenetik der Universität, Göttingen, Germany.
J Autoimmun. 1991 Jun;4(3):543-51. doi: 10.1016/0896-8411(91)90165-9.
The occurrence of diabetes mellitus was analysed in F2 hybrids bred from diabetic BB male rats and females of congenic rat strains carrying different major histocompatibility (RT1) haplotypes on the common LEW strain genetic background. Permissiveness for the disease in BB rats is probably determined by class II genes of the RT1 complex, which are also present in normal rats. Class I and class III genes, notably the Hsp70 genes in the class III region, do not appear to be involved. Among the diabetic F2 hybrids, about 90% are shown by DNA analysis to be homozygous for the class II genes of the permissive RT1 haplotype. The segregation patterns are in accord with the action of two independent recessive genes, one of them being RT1-linked.
在以普通LEW品系为遗传背景、携带不同主要组织相容性（RT1）单倍型的同类系大鼠品系的雌性大鼠与糖尿病BB雄性大鼠杂交培育出的F2代杂种中，对糖尿病的发病率进行了分析。BB大鼠对该疾病的易感性可能由RT1复合体的II类基因决定，这些基因在正常大鼠中也存在。I类和III类基因，特别是III类区域中的热休克蛋白70（Hsp70）基因，似乎并不参与其中。在糖尿病F2代杂种中，通过DNA分析显示，约90%对允许性RT1单倍型的II类基因是纯合的。分离模式符合两个独立隐性基因的作用，其中一个与RT1连锁。
