Crane Jennifer F, Trainor Paul A
Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, Missouri 64110, USA.
Annu Rev Cell Dev Biol. 2006;22:267-86. doi: 10.1146/annurev.cellbio.22.010305.103814.
Neural crest cells are a multipotent, migratory cell population that generates an astonishingly diverse array of cell types during vertebrate development. These include bones; tendons; neurons; glia; melanocytes; and connective, endocrine, and adipose tissue. With a limited capacity for self-renewal and a wide range of differentiation fates, neural crest cells bear many of the hallmarks of stem cells and persist throughout embryonic and adult development. But are all neural crest cells true stem cells, or do the majority of neural crest cells more closely resemble progenitor cells? In this review we discuss recent advances in characterizing the properties of neural crest cells, together with their potential for tissue-specific repair.
神经嵴细胞是一种多能的迁移性细胞群体，在脊椎动物发育过程中产生种类惊人的各种细胞类型。这些细胞类型包括骨骼、肌腱、神经元、神经胶质细胞、黑素细胞以及结缔组织、内分泌组织和脂肪组织。神经嵴细胞自我更新能力有限，分化命运广泛，具有许多干细胞的特征，并在胚胎发育和成年期持续存在。但是，所有神经嵴细胞都是真正的干细胞吗？还是大多数神经嵴细胞更类似于祖细胞？在这篇综述中，我们讨论了在表征神经嵴细胞特性及其组织特异性修复潜力方面的最新进展。
