Department of Biology, Tufts University, 200 Boston Avenue, Suite 4700, Medford, MA 02155, USA.
Int J Mol Sci. 2023 Aug 29;24(17):13358. doi: 10.3390/ijms241713358.
While the nervous system may be best known as the sensory communication center of an organism, recent research has revealed a myriad of multifaceted roles for both the CNS and PNS from early development to adult regeneration and remodeling. These systems work to orchestrate tissue pattern formation during embryonic development and continue shaping pattering through transitional periods such as metamorphosis and growth. During periods of injury or wounding, the nervous system has also been shown to influence remodeling and wound healing. The neuronal mechanisms responsible for these events are largely conserved across species, suggesting this evidence may be important in understanding and resolving many human defects and diseases. By unraveling these diverse roles, this paper highlights the necessity of broadening our perspective on the nervous system beyond its conventional functions. A comprehensive understanding of the complex interactions and contributions of the nervous system throughout development and adulthood has the potential to revolutionize therapeutic strategies and open new avenues for regenerative medicine and tissue engineering. This review highlights an important role for the nervous system during the patterning and maintenance of complex tissues and provides a potential avenue for advancing biomedical applications.
虽然神经系统作为生物体的感觉通讯中枢而广为人知，但最近的研究揭示了中枢神经系统和周围神经系统在从早期发育到成年再生和重塑的各个方面的多种作用。这些系统在胚胎发育过程中协调组织形态形成，并在变态和生长等过渡时期继续塑造形态。在受伤或受伤期间，神经系统也被证明会影响重塑和伤口愈合。负责这些事件的神经元机制在很大程度上在物种间保守，这表明这些证据对于理解和解决许多人类缺陷和疾病可能很重要。通过揭示这些不同的作用，本文强调了有必要超越神经系统的传统功能，从更广泛的角度来理解神经系统。全面了解神经系统在发育和成年期的复杂相互作用和贡献，有可能彻底改变治疗策略，并为再生医学和组织工程开辟新途径。这篇综述强调了神经系统在复杂组织的模式形成和维持中的重要作用，并为推进生物医学应用提供了一个潜在途径。
