Lewith G, Gabriel R
Curr Med Res Opin. 1975;3(4):199-202. doi: 10.1185/03007997509113671.
The nephrotic syndrome is the only hypoalbuminaemic state frequently associated with hyperlipidaemia. In the presence of a negative nitrogen balance, hyperlipidaemia is metabolically inappropriate and reflects the result of persistent breakaway from free fatty acid control. This lipid abnormality may result in the premature development of ischaemic heart disease in patients in whom it is not possible to control the primary renal abnormality. The authors suggest that future work should be directed towards thyroxine and insulin metabolism in nephrotic states.
肾病综合征是唯一经常与高脂血症相关的低白蛋白血症状态。在负氮平衡的情况下，高脂血症在代谢上是不适当的，反映了持续脱离游离脂肪酸控制的结果。这种脂质异常可能导致无法控制原发性肾脏异常的患者过早发生缺血性心脏病。作者建议，未来的工作应针对肾病状态下的甲状腺素和胰岛素代谢。
