Duits Ashley J, Rodriguez Tati, Schnog John-John B
Immunology Laboratory Department, Red Cross Blood Bank Foundation, Curaçao, Netherlands Antilles.
Br J Haematol. 2006 Jul;134(1):116-9. doi: 10.1111/j.1365-2141.2006.06103.x.
Hypoxia-induced angiogenesis may play an important role in the pathophysiology of sickle cell disease (SCD). Serum levels of angiopoietin (Ang)-1, Ang-2, vascular endothelial growth factor, placenta growth factor (PlGF), soluble tunica intima endothelial kinase 2 (sTIE2), erythropoietin (EPO) and endothelial activation markers (soluble vascular adhesion molecule-1, soluble intercellular adhesion molecule-1) were determined in controls, HbSS (n = 35) and HbSC (n = 23) patients. In the asymptomatic phase, serum Ang-2 (P < 0.001), EPO (P < 0.001) and sTIE2 (P = 0.03) were elevated in patients. During painful crises, increased Ang-2 (P < 0.001) and PlGF (P = 0.04) occurred in HbSS and Ang-2 (P = 0.05) in HbSC patients. These results indicate a pro-angiogenic state in SCD, mainly because of elevated Ang-2 levels.
缺氧诱导的血管生成可能在镰状细胞病（SCD）的病理生理学中起重要作用。在对照组、HbSS患者（n = 35）和HbSC患者（n = 23）中测定了血清血管生成素（Ang）-1、Ang-2、血管内皮生长因子、胎盘生长因子（PlGF）、可溶性内膜内皮激酶2（sTIE2）、促红细胞生成素（EPO）和内皮激活标志物（可溶性血管细胞黏附分子-1、可溶性细胞间黏附分子-1）的水平。在无症状期，患者血清中的Ang-2（P < 0.001）、EPO（P < 0.001）和sTIE2（P = 0.03）升高。在疼痛危象期间，HbSS患者的Ang-2（P < 0.001）和PlGF（P = 0.04）升高，HbSC患者的Ang-2（P = 0.05）升高。这些结果表明SCD存在促血管生成状态，主要是由于Ang-2水平升高。
