哺乳动物中的RNA调控
RNA regulation in mammals.
作者信息
Szymanski Maciej, Barciszewski Jan
机构信息
Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznan, Poland.
出版信息
Ann N Y Acad Sci. 2006 May;1067:461-8. doi: 10.1196/annals.1354.066.
Noncoding RNAs (ncRNA) are ubiquitous regulatory factors affecting gene expression in all organisms. In eukaryotes ncRNAs have been shown to operate on virtually every level of transmission of genetic information. They are implicated in processes that are crucial for the correct growth and development of multicellular organisms. Changes in their expression are often related to stress conditions or associated with diseases or developmental disorders.
非编码RNA(ncRNA)是影响所有生物体基因表达的普遍存在的调控因子。在真核生物中,ncRNA已被证明几乎在遗传信息传递的每个层面都发挥作用。它们参与了多细胞生物正确生长和发育所必需的过程。其表达的变化通常与应激条件有关,或与疾病或发育障碍相关。