Amaral Paulo P, Dinger Marcel E, Mercer Tim R, Mattick John S
Institute for Molecular Bioscience, University of Queensland, St. Lucia QLD 4072, Australia.
Science. 2008 Mar 28;319(5871):1787-9. doi: 10.1126/science.1155472.
The past few years have revealed that the genomes of all studied eukaryotes are almost entirely transcribed, generating an enormous number of non-protein-coding RNAs (ncRNAs). In parallel, it is increasingly evident that many of these RNAs have regulatory functions. Here, we highlight recent advances that illustrate the diversity of ncRNA control of genome dynamics, cell biology, and developmental programming.
过去几年的研究表明，所有已研究的真核生物基因组几乎都能完全转录，产生大量非蛋白质编码RNA（ncRNA）。与此同时，越来越明显的是，这些RNA中有许多具有调控功能。在此，我们重点介绍一些最新进展，这些进展展示了ncRNA在基因组动态、细胞生物学和发育编程控制方面的多样性。
