Bosy-Westphal Anja, Danielzik Sandra, Dörhöfer Ralf-Peter, Later Wiebke, Wiese Sonja, Müller Manfred J
Institut für Humanernährung und Lebensmittelkunde, Christian-Albrechts-University Kiel, Kiel, Germany.
JPEN J Parenter Enteral Nutr. 2006 Jul-Aug;30(4):309-16. doi: 10.1177/0148607106030004309.
The use of bioelectrical impedance phase angle has been recommended as a prognostic tool in the clinical setting, but published reference data bases are discrepant and incomplete (eg, they do not consider body mass index [BMI], and data are lacking for children).
Phase angle reference values stratified by age, sex, and BMI were generated in a large German data base of 15,605 children and adolescents and 214,732 adults, and the determinants of phase angle values were assessed. The reference values were applied to 3 groups of patients and compared with previously published reference values from the United States and Switzerland.
Gender and age were the main determinants of phase angle in adults, with men and younger subjects having higher phase angles. In children and adolescents, age and BMI were the main determinants of phase angle. In normal and overweight adults, phase angle increased with increasing BMI, but there was an inverse association at a BMI >40 kg/m2. In cirrhosis, the prevalence of a low phase angle increased with the state of disease, whereas it was not different between patients with the metabolic syndrome and controls. There are considerable differences between phase angle reference values from different populations. These differences are not explained by age or BMI and may be due to differences between impedance analyzers.
The determinants of phase angle differ between adults and children. In adults, the influence of BMI on phase angle depended on the BMI range. The prognostic value of phase angle may differ in different clinical settings. The use of population-specific and probably impedance-analyzer-specific reference values for phase angle is recommended.
生物电阻抗相角已被推荐作为临床环境中的一种预后工具，但已发表的参考数据库存在差异且不完整（例如，它们未考虑体重指数[BMI]，且缺乏儿童数据）。
在一个包含15605名儿童和青少年以及214732名成年人的大型德国数据库中生成了按年龄、性别和BMI分层的相角参考值，并评估了相角值的决定因素。将这些参考值应用于3组患者，并与美国和瑞士先前发表的参考值进行比较。
性别和年龄是成年人相角的主要决定因素，男性和较年轻的受试者相角较高。在儿童和青少年中，年龄和BMI是相角的主要决定因素。在正常和超重成年人中，相角随BMI增加而增加，但在BMI>40kg/m²时呈负相关。在肝硬化中，低相角的患病率随疾病状态增加，而代谢综合征患者与对照组之间无差异。不同人群的相角参考值存在相当大的差异。这些差异不能用年龄或BMI来解释，可能是由于阻抗分析仪之间的差异。
成年人和儿童相角的决定因素不同。在成年人中，BMI对相角的影响取决于BMI范围。相角的预后价值在不同临床环境中可能不同。建议使用特定人群且可能是特定阻抗分析仪的相角参考值。
