Lee Yong Su, Cho Yong Kyun, Pae Ji Cheul, Oh Se Yong, Kang Mun Su, Park Jung Ho, Kim Hong Joo, Park Dong Il, Sohn Chong Il, Jeon Woo Kyu, Kim Byung Ik, Lee Won Young, Oh Ki Won, Yun Eun Joo, Oh Eun Sook
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Korean J Hepatol. 2006 Jun;12(2):221-9.
BACKGROUND/AIMS: Nonalcoholic fatty liver disease (NAFLD) comprises a large part of chronic liver diseases. Recently it was reported that adipokines are closely associated with the common risk factors for NAFLD, such as obesity, diabetes, dyslipidemia, and insulin resistance. We aimed to evaluate the changes in serum adiponectin, resistin and leptin concentrations related to alanine aminotransferase (ALT) elevations in Korean men with NAFLD.
We studies 38 men who were diagnosed with fatty liver by abdominal ultrasonography. None had a history of excessive alcohol consumption, autoimmune hepatitis, inherited or metabolic liver disease or viral hepatitis. The subjects were divided into two groups. One group had normal levels of ALT (n=28) and the other had increased ALT (n=10). We compared anthropometrical parameters, biochemical items and serum adipokine levels between these two groups.
Serum adiponectin levels were lower in the increased ALT group than in the normal ALT group (3.89 +/- 1.77 vs 7.01 +/- 2.54 microgram/dL, P=0.001). But there were no significant differences in serum leptin and resistin levels between two groups (4.02 +/- 2.04 vs 3.26 +/- 1.41 ng/mL, p=0.245, 80.14 +/- 14.8 vs 80.5 +/- 11.34 ng/mL, P=0.937, respectively). Multiple linear regression analyses demonstrated that the serum adiponectin level is inversely correlated with serum ALT level and that the serum aspartate aminotransferase (AST) level is positively correlated with the serum ALT level.
Our study shows that hypoadiponectinemia is associated with an ALT elevation in patients with NAFLD. Adiponectin may play an indirect role in the development of NAFLD.
背景/目的：非酒精性脂肪性肝病（NAFLD）是慢性肝病的重要组成部分。最近有报道称，脂肪因子与NAFLD的常见危险因素密切相关，如肥胖、糖尿病、血脂异常和胰岛素抵抗。我们旨在评估韩国男性NAFLD患者血清脂联素、抵抗素和瘦素浓度与丙氨酸氨基转移酶（ALT）升高的关系。
我们研究了38名经腹部超声诊断为脂肪肝的男性。他们均无过量饮酒史、自身免疫性肝炎、遗传性或代谢性肝病或病毒性肝炎病史。将受试者分为两组。一组ALT水平正常（n = 28），另一组ALT升高（n = 10）。我们比较了两组之间的人体测量参数、生化指标和血清脂肪因子水平。
ALT升高组的血清脂联素水平低于ALT正常组（3.89±1.77 vs 7.01±2.54微克/分升，P = 0.001）。但两组之间的血清瘦素和抵抗素水平无显著差异（分别为4.02±2.04 vs 3.26±1.41纳克/毫升，p = 0.245；80.14±14.8 vs 80.5±11.34纳克/毫升，P = 0.937）。多元线性回归分析表明，血清脂联素水平与血清ALT水平呈负相关，血清天冬氨酸氨基转移酶（AST）水平与血清ALT水平呈正相关。
我们的研究表明，低脂联素血症与NAFLD患者的ALT升高有关。脂联素可能在NAFLD的发生发展中起间接作用。
