Sterzl Ivan, Prochazkova Jarmila, Hrda Pavlina, Matucha Petr, Bartova Jirina, Stejskal Vera
Institute of Immunology and Microbiology, 1st Medical Faculty, Charles University, General Faculty Hospital, Prague, Czech Republic.
Neuro Endocrinol Lett. 2006 Dec;27 Suppl 1:25-30.
The impact of dental amalgam removal on the levels of anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-Tg) antibodies was studied in patients with autoimmune thyroiditis (AT) with and without mercury allergy.
Thirty-nine patients with AT were tested by an optimized lymphocyte proliferation test MELISA for allergy (hypersensitivity) to inorganic mercury. Patients were divided into two groups: Group I (n = 12) with no hypersensitivity to mercury and Group II (n = 27) with hypersensitivity to mercury. Amalgam fillings were removed from the oral cavities of 15 patients with hypersensitivity to mercury (Group IIA) and left in place in the remaining 12 patients (Group IIB). The laboratory markers of AT, anti-TPO and anti-Tg autoantibodies, were determined in all groups at the beginning of the study and six months later.
Compared to levels at the beginning of the study, only patients with mercury hypersensitivity who underwent amalgam replacement (Group IIA) showed a significant decrease in the levels of both anti-Tg (p=0.001) and anti-TPO (p=0.0007) autoantibodies. The levels of autoantibodies in patients with or without mercury hypersensitivity (Group I and Group IIB) who did not replace amalgam did not change.
Removal of mercury-containing dental amalgam in patients with mercury hypersensitivity may contribute to successful treatment of autoimmune thyroiditis.
研究在有或没有汞过敏的自身免疫性甲状腺炎（AT）患者中，去除牙科汞合金对抗甲状腺过氧化物酶（抗-TPO）和抗甲状腺球蛋白（抗-Tg）抗体水平的影响。
采用优化的淋巴细胞增殖试验MELISA对39例AT患者进行无机汞过敏（超敏反应）检测。患者分为两组：I组（n = 12）对汞无超敏反应，II组（n = 27）对汞有超敏反应。从15例对汞过敏的患者（IIA组）口腔中取出汞合金填充物，其余12例患者（IIB组）保留填充物。在研究开始时和6个月后测定所有组中AT的实验室标志物抗-TPO和抗-Tg自身抗体。
与研究开始时的水平相比，只有进行汞合金置换的汞超敏患者（IIA组）的抗-Tg（p = 0.001）和抗-TPO（p = 0.0007）自身抗体水平显著降低。未置换汞合金的有或无汞超敏反应的患者（I组和IIB组）的自身抗体水平没有变化。
对汞超敏的患者去除含汞牙科汞合金可能有助于成功治疗自身免疫性甲状腺炎。
