Lunde N M, Port F K, Wolfe R A, Guire K E
Department of Medicine, Medical School, University of Michigan, Ann Arbor.
Adv Perit Dial. 1991;7:68-72.
To evaluate patient survival among geriatric patients by dialytic treatment of choice we assigned all patients aged 65 years and older treated in Michigan to either CAPD at home or center hemodialysis (HD) according to the treatment used on day 120 of ESRD therapy. Michigan Kidney Registry files on all 308 CAPD and 1244 HD patients who started ESRD therapy during 1980-1987 were used for this study. The Cox proportional hazards model revealed a significantly increased relative death rate (RR) for patients with diabetes (RR = 1.91, p less than 0.001) and hypertension (RR 1.4, p less than 0.01) as cause of ESRD when adjusting for age, sex, race, treatment and year of incidence. White patients had a 51% higher relative death rate overall when compared to black patients (p less than 0.001) and specifically among hypertensive (RR = 1.65, p less than 0.001) and diabetic patients (RR = 1.59, p less than 0.001). Those differences were still significant when taking higher rates of withdrawal from dialysis among white patients into account. The relative death rates for CAPD patients was essentially the same as for HD patients overall, however, diabetic CAPD patients appeared to have a higher than diabetic HD patients (RR = 1.58, p = 0.1). This statistically not significant difference may be related to selection of patients with cardiovascular risk into CAPD. There was no trend in mortality over time. By modality on day 120, CAPD has similar outcomes as HD in geriatric non diabetic patients.
为了通过选择的透析治疗方式评估老年患者的生存率,我们根据终末期肾病(ESRD)治疗第120天所采用的治疗方式,将密歇根州所有65岁及以上接受治疗的患者分为家庭持续性非卧床腹膜透析(CAPD)组或中心血液透析(HD)组。本研究使用了密歇根肾脏登记处关于1980 - 1987年间开始ESRD治疗的308例CAPD患者和1244例HD患者的档案。Cox比例风险模型显示,在对年龄、性别、种族、治疗方式和发病年份进行校正后,因糖尿病(相对风险率[RR]=1.91,p<0.001)和高血压(RR = 1.4,p<0.01)导致ESRD的患者相对死亡率显著增加。与黑人患者相比,白人患者总体相对死亡率高51%(p<0.001),在高血压患者(RR = 1.65,p<0.001)和糖尿病患者中尤其如此(RR = 1.59,p<0.001)。考虑到白人患者中较高的透析退出率,这些差异仍然显著。总体而言,CAPD患者的相对死亡率与HD患者基本相同,然而,糖尿病CAPD患者的相对死亡率似乎高于糖尿病HD患者(RR = 1.58,p = 0.1)。这种统计学上不显著的差异可能与选择有心血管风险的患者进行CAPD治疗有关。死亡率没有随时间变化的趋势。在第120天按治疗方式来看,在老年非糖尿病患者中,CAPD与HD的结局相似。