Gagliotti C, Morsillo F, Resi D, Milandri M, Moro M L
Area di Programma Rischio Infettivo, Agenzia Sanitaria Regionale Emilia-Romagna, Viale Aldo Moro 21, 40127 Bologna, Italy.
Infection. 2006 Jun;34(3):155-7. doi: 10.1007/s15010-006-5106-8.
This study aims to describe the pattern of antibiotic treatments in the community for children ages 0-23 months in Emilia-Romagna (a northern Italy region) pointing out possible changes of prescribed agents when first treatments in the life of each children are compared to successive ones.
The Regional Drug Prescription and the Resident Population databases were used as data sources to study the cohort of children born between January 1 and December 31, 2000 and resident in Emilia-Romagna.
The cumulative incidences of children with at least one treatment were 22%, 55% and 82% at 6, 12 and 24 months of age, respectively. Broad spectrum penicillins were the most prescribed antibiotic class for children at their first treatment while cephalosporins were the most prescribed class for successive treatments and when pooling all treatments.
Cephalosporins and other second line antibiotics are frequently prescribed to 0 to 23-month-old residents in Emilia-Romagna even when only first treatments are considered; further research is needed to quantify inappropriateness of antibiotic prescription.
本研究旨在描述意大利北部艾米利亚 - 罗马涅地区0至23个月儿童在社区中的抗生素治疗模式，指出将每个儿童首次治疗与后续治疗相比较时，所开药物可能存在的变化。
使用地区药物处方和常住人口数据库作为数据源，研究2000年1月1日至12月31日在艾米利亚 - 罗马涅出生并居住的儿童队列。
至少接受过一次治疗的儿童在6个月、12个月和24个月时的累积发病率分别为22%、55%和82%。广谱青霉素是儿童首次治疗时最常开具的抗生素类别，而头孢菌素是后续治疗以及汇总所有治疗时最常开具的类别。
即使仅考虑首次治疗，头孢菌素和其他二线抗生素在艾米利亚 - 罗马涅0至23个月大的居民中也经常被开具；需要进一步研究以量化抗生素处方的不适当性。
