[使用羟丙基瓜尔胶治疗的患者角膜通透性降低：一项荧光光度法研究]
[Reduction of corneal permeability in patients treated with HP-guar: a fluorophotometric study].
作者信息
Cerván-López I, Sáenz-Francés-San-Baldomero F, Benítez-Del-Castillo J M, García-Sánchez J
机构信息
Hospital Universitario Clínico San Carlos, Universidad Complutense, Madrid, España.
出版信息
Arch Soc Esp Oftalmol. 2006 Jun;81(6):327-32. doi: 10.4321/s0365-66912006000600006.
INTRODUCTION
The incidence of dry eye disease, which mainly affects the corneal epithelium, is rising. The main treatment is still the use of artificial tears capable of improving the humidification and lubrication of the corneal epithelium, and avoiding its progressive functional failure. HP-Guar is a new compound used for this purpose.
METHODS
We performed a prospective, masked and paired study on the left eye of 10 patients suffering from dry eye disease. Corneal permeability measurements were performed by fluorophotometry after instilling 40 microL of a solution of 2% sodium fluorescein, before and after treatment with the HP-Guar drops. The results were analysed using Wilcoxon test for paired data.
RESULTS
A mean decrease in corneal permeability of 45%, after the use of HP-Guar drops was found (p=0.002).
CONCLUSIONS
HP-Guar provides a new therapeutic option significantly decreasing corneal epithelial permeability.
引言
主要影响角膜上皮的干眼症发病率正在上升。主要治疗方法仍然是使用能够改善角膜上皮湿润和润滑并避免其进行性功能衰竭的人工泪液。HP-瓜尔胶是用于此目的的一种新化合物。
方法
我们对10例干眼症患者的左眼进行了一项前瞻性、双盲和配对研究。在用HP-瓜尔胶滴眼液治疗前后，滴入40微升2%荧光素钠溶液后，通过荧光光度法测量角膜通透性。使用配对数据的Wilcoxon检验分析结果。
结果
使用HP-瓜尔胶滴眼液后，发现角膜通透性平均降低了45%（p=0.002）。
结论
HP-瓜尔胶提供了一种新的治疗选择，可显著降低角膜上皮通透性。
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