Asensio-Sánchez V M, Torreblanca-Agüera B, Martínez-Calvo S, Calvo M J, Rodríguez R
Hospital General, Medina del Campo, Valladolid, España.
Arch Soc Esp Oftalmol. 2006 Jun;81(6):345-8. doi: 10.4321/s0365-66912006000600010.
We describe 2 patients who developed ocular side effects during treatment with topiramate. One was a 16-year-old woman with generalized seizures who developed a homonymous hemianopia after using topiramate 125 mg per day for 12 weeks, and the other was a 24-year-old epileptic female who developed a bilateral maculopathy after using topiramate 150 mg per day for 8 weeks.
We identified two severe ocular adverse reactions from topiramate. Both reactions necessitated discontinuing the treatment, but the topiramate-associated maculopathy was irreversible.
我们描述了2例在托吡酯治疗期间出现眼部副作用的患者。1例为16岁患有全身性癫痫的女性，在每天服用125毫克托吡酯12周后出现同向性偏盲；另1例为24岁的癫痫女性，在每天服用150毫克托吡酯8周后出现双侧黄斑病变。
我们确定了托吡酯引起的两种严重眼部不良反应。两种反应均需要停止治疗，但托吡酯相关的黄斑病变是不可逆的。
