UOC Neurology and Neurophysiopathology, Ospedale Sandro Pertini, Via Monti Tiburtini 385, 00157 Rome, Italy.
Neurol Sci. 2012 Apr;33(2):419-21. doi: 10.1007/s10072-011-0755-5. Epub 2011 Sep 7.
We describe a 43-year-old patient who experienced visual loss 4 years after beginning antiepileptic therapy with topiramate. Ophthalmological and neurological examinations led to a preliminary diagnosis of bilateral toxic optic neuritis. Mitochondrial genome sequence analysis detected a Leber hereditary optic neuropathy 11778G>A mutation. The possibility that topiramate might favor a conversion disease, alerts physicians to seek a history of blindness in patients undergoing chronic antiepileptic therapy.
我们描述了一位 43 岁的患者，他在开始使用托吡酯进行抗癫痫治疗 4 年后出现视力丧失。眼科和神经科检查导致初步诊断为双侧中毒性视神经炎。线粒体基因组序列分析检测到莱伯遗传性视神经病变 11778G>A 突变。托吡酯可能有利于转化疾病的可能性提醒医生在接受慢性抗癫痫治疗的患者中寻找失明病史。
