交叉复分解反应作为合成前列环素和前列腺素类似物的通用策略。
Cross metathesis as a general strategy for the synthesis of prostacyclin and prostaglandin analogues.
作者信息
Sheddan Neil A, Mulzer Johann
机构信息
Institut für Organische Chemie, Wien, Austria.
出版信息
Org Lett. 2006 Jul 6;8(14):3101-4. doi: 10.1021/ol061141u.
PMID:16805562
Abstract
[reaction: see text] A cross metathesis (CM) approach has been successfully applied to introduce fully functionalized omega-side chain appendages of various prostacyclin and prostaglandin analogues, resulting in high (E)-selectivities for the C13-C14 double bond and leading to the total syntheses of isocarbacyclin, 15R-TIC, carbacyclin, and PGF(2)(alpha) and the formal syntheses of 15-deoxy-TIC and PGJ(2).
摘要
[反应：见正文] 交叉复分解（CM）方法已成功应用于引入各种前列环素和前列腺素类似物的全功能化ω-侧链附属物，从而实现C13-C14双键的高（E）选择性，并导致异卡前列素、15R-TIC、卡前列素和PGF(2)(α)的全合成以及15-脱氧-TIC和PGJ(2)的形式合成。
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