人绒毛膜生长催乳素的脂解作用。

Lipolytic action of human chorionic somatomammotropin.

作者信息

Mochizuki M, Morikawa H, Ohga Y, Tojo S

出版信息

Endocrinol Jpn. 1975 Apr;22(2):123-9. doi: 10.1507/endocrj1954.22.123.

DOI:10.1507/endocrj1954.22.123

Abstract

Human chorionic somatomammotropin extracted and purified from placenta at term was proved to have a lipolytic action in the epididymal fat pad of rats. The following mechanism appears to be involved in the lipolytic action of the hormone; human chorionic somatomammotropin activates adenyl cyclase, thereby increasing the concentration of cyclic AMP in the tissue, which, in turn, activates protein kinase to lead to the activation of hormone sensitive lipase.

摘要

从足月胎盘提取和纯化的人绒毛膜生长催乳素被证明对大鼠附睾脂肪垫有脂解作用。该激素的脂解作用可能涉及以下机制：人绒毛膜生长催乳素激活腺苷酸环化酶，从而增加组织中环磷酸腺苷（cAMP）的浓度，进而激活蛋白激酶，导致激素敏感性脂肪酶的激活。