二倍体脑膜瘤中3号染色体q24至qter带的杂合性缺失。

Loss of heterozygosity on chromosome 3, bands q24----qter, in a diploid meningioma.

作者信息

Färber U, Schneider G, Schrell U M, Fahlbusch P, Adams E F, Blin N, Henn W

机构信息

Institut für Humangenetik, Universitätsklinik, Homburg, Germany.

出版信息

Cytogenet Cell Genet. 1991;57(2-3):157-8. doi: 10.1159/000133136.

DOI:10.1159/000133136

PMID:1680607

Abstract

Cytogenetic analysis of a meningioma from a 46-year-old female patient exhibited as the sole cytogenetic aberration a deletion on the long arm of one chromosome 3 involving bands 3q24----qter. To verify this finding, RFLP analysis was performed with two polymorphic probes, MOX2 and D3S5. The patient was informative for both single copy probes and demonstrated loss of heterozygosity in the region above whereas chromosome 22 displayed no loss of heterozygosity as judged by a proximal and a distal probe.

摘要

对一名46岁女性患者的脑膜瘤进行细胞遗传学分析，结果显示唯一的细胞遗传学异常是一条3号染色体长臂上3q24至qter带的缺失。为验证这一发现，使用两个多态性探针MOX2和D3S5进行了RFLP分析。该患者对两个单拷贝探针均呈信息性，且上述区域显示杂合性缺失，而通过近端和远端探针判断，22号染色体未显示杂合性缺失。