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22号染色体长臂和17号染色体短臂杂合性缺失与脑膜瘤的侵袭性相关。

Loss of heterozygosity on chromosome 22q and 17p correlates with aggressiveness of meningiomas.

作者信息

Kim J H, Lee S H, Rhee C H, Park S Y, Lee J H

机构信息

Department of Neurosurgery, College of Medicine, Sung Kyun Kwan University, Seoul, Korea.

出版信息

J Neurooncol. 1998 Nov;40(2):101-6. doi: 10.1023/a:1006110812240.

Abstract

According to reported cytogenetic studies, there is a significant association between chromosomal aberrations and aggressiveness in meningiomas. With the method of restriction fragment length polymorphism analysis (RFLP), we examined tumor specific LOH on chromosome 17p and 22q in 30 cases of intracranial meningiomas. There were eight cases of meningiomas with aggressive characteristics, such as invasive meningioma, malignant meningioma, hemangiopericytic meningioma, and multiple meningiomas with central neurofibromatosis. Twenty-five of 30 cases (83%) were constitutionally heterozygous for at least one of the chromosome 22q DNA markers and sixteen of 25 informative cases (64%) displayed loss of heterozygosity (LOH). All of the 8 informative cases (100%) of meningiomas with aggressive characteristics, showed LOH on chromosome 22q whereas non-aggressive cases revealed LOH in eight of 17 informative cases (47%). At the loci on chromosome 17p, only two cases of malignant meningionas showed LOH. Our results suggest that the inactivations of putative tumor suppressor genes on chromosome 22q and 17p may correlate with aggressiveness and malignant transformation of meningiomas.

摘要

根据已报道的细胞遗传学研究,染色体畸变与脑膜瘤的侵袭性之间存在显著关联。我们采用限制性片段长度多态性分析(RFLP)方法,检测了30例颅内脑膜瘤中17p和22q染色体上的肿瘤特异性杂合性缺失(LOH)。有8例具有侵袭性特征的脑膜瘤,如侵袭性脑膜瘤、恶性脑膜瘤、血管外皮细胞瘤性脑膜瘤以及伴有中枢神经纤维瘤病的多发脑膜瘤。30例中有25例(83%)在22q染色体的至少一个DNA标记位点上为 constitutionally杂合子,25例信息充分的病例中有16例(64%)表现出杂合性缺失(LOH)。所有8例(100%)具有侵袭性特征的脑膜瘤信息充分的病例,均在22q染色体上显示出LOH,而无侵袭性的病例在17例信息充分的病例中有8例(47%)显示出LOH。在17p染色体位点上,只有2例恶性脑膜瘤显示出LOH。我们的结果表明,22q和17p染色体上假定的肿瘤抑制基因的失活可能与脑膜瘤的侵袭性和恶性转化相关。

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