4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate.

作者信息

Wood Jill, Bagi Cedo M, Akuche Christiana, Bacchiocchi Antonietta, Baryza Jeremy, Blue Marie-Luise, Brennan Catherine, Campbell Ann-Marie, Choi Soongyu, Cook James H, Conrad Patricia, Dixon Brian R, Ehrlich Paul P, Gane Todd, Gunn David, Joe Ted, Johnson Jeffrey S, Jordan Jerold, Kramss Richard, Liu Peiying, Levy Joan, Lowe Derek B, McAlexander Ian, Natero Reina, Redman Anikó M, Scott William J, Town Christopher, Wang Ming, Wang Yamin, Zhang Zhonghua

机构信息

Bayer Research Center, Bayer HealthCare, Pharmaceutical Division, 400 Morgan Lane, West Haven, CT 06516, USA.

出版信息

Bioorg Med Chem Lett. 2006 Sep 15;16(18):4965-8. doi: 10.1016/j.bmcl.2006.06.041. Epub 2006 Jun 27.

A series of 4,5-disubstituted cis-pyrrolidinones was investigated as inhibitors of 17beta-HSD II for the treatment of osteoporosis. Biochemical data for several compounds are given. Compound 42 was selected as the lead candidate.