Department of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, NO-4036 Stavanger, Norway.
Molecules. 2021 Jan 11;26(2):341. doi: 10.3390/molecules26020341.
Natural products are rich sources of interesting scaffolds possessing a plethora of biological activity. With the isolation of the martinella alkaloids in 1995, namely martinelline and martinellic acid, the pyrrolo[3,2-c]quinoline scaffold was discovered. Since then, this scaffold has been found in two additional natural products, viz. incargranine B and seneciobipyrrolidine. These natural products have attracted attention from synthetic chemists both due to the interesting scaffold they contain, but also due to the biological activity they possess. This review highlights the synthetic efforts made for the preparation of these alkaloids and formation of analogues with interesting biological activity.
天然产物是具有丰富生物活性的有趣骨架的丰富来源。1995 年分离出马丁内拉生物碱，即马丁内林和马丁内拉酸，发现了吡咯并[3,2-c]喹啉骨架。此后，该骨架在另外两种天然产物中被发现，即 incargranine B 和 seneciobipyrrolidine。这些天然产物引起了合成化学家的关注，不仅因为它们含有有趣的骨架，还因为它们具有生物活性。本文综述了为制备这些生物碱及其具有有趣生物活性的类似物所做的合成工作。
