山羊皮下注射马波沙星后的药代动力学行为及药代动力学/药效动力学整合

Pharmacokinetic behavior and pharmacokinetic/pharmacodynamic integration of marbofloxacin after subcutaneous administration in goats.

作者信息

Dova Samanta Waxman, San Andrés M Dolores, González Fernando, San Andrés Manuel I, De Lucas José J, Rodríguez Casilda

机构信息

Cátedra de Farmacología, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Argentina.

出版信息

Vet J. 2007 Sep;174(2):425-7. doi: 10.1016/j.tvjl.2006.05.004. Epub 2006 Jun 27.

DOI:10.1016/j.tvjl.2006.05.004

PMID:16807010

Abstract

The pharmacokinetic behavior of marbofloxacin was studied in goats after single-dose subcutaneous (SC) administration of 2mg/kg bodyweight. Drug concentration in plasma was determined by high performance liquid chromatography and the data obtained were subjected to non-compartmental kinetic analysis. Marbofloxacin peak plasma concentration (C(max)=1.77+/-0.24microg/mL) was reached 1.25+/-0.50h (T(max)) after SC administration. The elimination half-life (t(1/2beta)) and area under curve (AUC) were 5.74+/-1.21h and 8.15 vs 2.33microg h/mL, respectively. Taking into account the values obtained for the efficacy indices, it was concluded that a SC dose of 2mg/kg/24h of marbofloxacin could be adequate to treat infections caused by high susceptible bacteria like Escherichia coli or Salmonella spp.

摘要

在山羊单剂量皮下注射2mg/kg体重的麻保沙星后，对其药代动力学行为进行了研究。通过高效液相色谱法测定血浆中的药物浓度，并对所得数据进行非房室动力学分析。皮下注射后1.25±0.50小时（Tmax）达到麻保沙星血浆峰浓度（Cmax = 1.77±0.24μg/mL）。消除半衰期（t1/2β）和曲线下面积（AUC）分别为5.74±1.21小时和8.15对2.33μg h/mL。考虑到疗效指标的所得值，得出结论：2mg/kg/24h的皮下注射麻保沙星剂量可能足以治疗由高敏感性细菌如大肠杆菌或沙门氏菌属引起的感染。