Sunish I P, Rajendran R, Mani T R, Munirathinam A, Reuben R, Dash A P
Centre for Research in Medical Entomology (Indian Council of Medical Research), 4 Sarojini Street, Chinna Chokkikulam, Madurai-625 002, Tamil Nadu, India.
Parasitol Int. 2006 Sep;55(3):233-6. doi: 10.1016/j.parint.2006.05.003. Epub 2006 Jun 27.
The impact of single dose mass drug administration of diethylcarbamazine (DEC), DEC with albendazole (ALB), and ivermectin (IVR) with albendazole, was examined on the human bancroftian filarial infections in village scale trials in south India, from a follow-up study after 2 years. The treatment arms administered with DEC alone and DEC+ALB demonstrated long-term benefits in reducing microfilaraemia significantly (P<0.05), while antigenaemia reduction was negligible. The arm with ALB+IVR did not show such reductions. Among the antigenaemic and microfilaraemic individuals, 87% became amicrofilaraemic in DEC+ALB arm, which were higher than that observed in the other 2 treatment arms. Among amicrofilaraemics (but Ag+), nearly 35% cleared of infection in DEC+ALB, while 26% and 6% in DEC alone and IVR+ALB arms, respectively. The drug combination DEC+ALB was observed to demonstrate a significant impact in reducing filarial infection even after 2 years post treatment.
在印度南部乡村规模的试验中，通过两年后的随访研究，考察了单剂量群体服药使用乙胺嗪（DEC）、乙胺嗪联合阿苯达唑（ALB）以及伊维菌素（IVR）联合阿苯达唑对人体班氏丝虫感染的影响。单独使用DEC以及DEC + ALB的治疗组在显著降低微丝蚴血症方面显示出长期益处（P<0.05），而抗原血症的降低可忽略不计。ALB + IVR组未显示出此类降低情况。在抗原血症和微丝蚴血症个体中，DEC + ALB组有87%变为无微丝蚴血症，高于其他两个治疗组。在无微丝蚴血症（但抗原阳性）者中，DEC + ALB组近35%清除感染，而单独使用DEC组和IVR + ALB组分别为26%和6%。观察发现，即使在治疗后两年，药物组合DEC + ALB在减少丝虫感染方面仍显示出显著影响。
