Ramírez M, Lucia A, Gómez-Gallego F, Esteve-Lanao J, Pérez-Martínez A, Foster C, Andreu A L, Martin M A, Madero L, Arenas J, García-Castro J
Servicio de Oncohematología y Transplante, Hospital Universitario Niño Jesús, Avda Menéndez Pelayo 65, 28009 Madrid, Spain.
Br J Sports Med. 2006 Aug;40(8):719-22. doi: 10.1136/bjsm.2006.028639. Epub 2006 Jun 28.
Mesenchymal cells recruited to damaged tissues must circulate through the bloodstream. The absolute numbers of circulating mesenchymal stem cells (cMSCs) in two different models of acute and chronic skeletal muscle injury were determined. cMSCs were present in significantly higher numbers in both models than in healthy controls. These results support the hypothesis that MSCs are mobilised into the bloodstream after skeletal muscle tissue damage. These two models (acute and chronic) would be of value in the search for molecular mediators of mobilisation of MSCs into the circulation.
招募至受损组织的间充质细胞必须通过血液循环。测定了急性和慢性骨骼肌损伤两种不同模型中循环间充质干细胞（cMSC）的绝对数量。在这两种模型中，cMSC的数量均显著高于健康对照。这些结果支持了骨骼肌组织损伤后间充质干细胞被动员进入血液循环的假说。这两种模型（急性和慢性）对于寻找间充质干细胞动员进入循环的分子介质具有重要价值。
