Faraldo Marisa M, Teulière Jérôme, Deugnier Marie-Ange, Taddei-De La Hosseraye Ilaria, Thiery Jean Paul, Glukhova Marina A
Institut Curie, CNRS UMR144, 26 rue d'Ulm, 75248, Paris Cedex 05, France.
J Mammary Gland Biol Neoplasia. 2005 Jul;10(3):211-9. doi: 10.1007/s10911-005-9582-8.
Until recently, myoepithelial cells-the second major cell population in the mammary epithelium-were not considered to play an important role in the morphogenetic events during gland development. Mouse mutants with changes in the gene expression pattern characteristic of the basal myoepithelial cell layer have been generated and used to show that these cells influence the proliferation, survival and differentiation of luminal cells, modulate stromal-epithelial interactions and actively participate in mammary morphogenesis. Various cellular and molecular mechanisms may underlie the observed phenotypes. These include an unbalanced expression of matrix degrading metalloproteinases (MMPs) and their inhibitors, leading to changes in the composition and organization of the (extracellular matrix) ECM, the production of soluble growth factors affecting stromal and epithelial cell growth and differentiation and direct signaling through cell-cell contacts between the myoepithelial and luminal cell layers.
直到最近，肌上皮细胞（乳腺上皮中的第二大主要细胞群体）在腺体发育过程的形态发生事件中都未被认为发挥重要作用。已产生具有基底肌上皮细胞层特征性基因表达模式变化的小鼠突变体，并用于表明这些细胞影响管腔细胞的增殖、存活和分化，调节基质 - 上皮相互作用，并积极参与乳腺形态发生。各种细胞和分子机制可能是观察到的表型的基础。这些机制包括基质降解金属蛋白酶（MMPs）及其抑制剂的不平衡表达，导致（细胞外基质）ECM的组成和组织发生变化，产生影响基质和上皮细胞生长与分化的可溶性生长因子，以及通过肌上皮细胞层和管腔细胞层之间的细胞 - 细胞接触进行直接信号传导。
