人脑海马星形胶质细胞在γ干扰素处理后介导肿瘤坏死因子相关凋亡诱导配体（TRAIL）介导的细胞凋亡。
Human brain astrocytes mediate TRAIL-mediated apoptosis after treatment with IFN-gamma.
作者信息
Lee Jeonggi, Shin Jeon-Soo, Choi In-Hong
机构信息
Department of Microbiology, Institute for Immunology and Immunological Diseases, Seoul, Korea.
出版信息
Yonsei Med J. 2006 Jun 30;47(3):354-8. doi: 10.3349/ymj.2006.47.3.354.
TNF-related apoptosis inducing ligand (TRAIL) expressions were studied in primary human brain astrocytes in response to pro-inflammatory cytokines. When astrocytes were treated with IL-1beta, TNF-alpha or IFN-gamma, TRAIL was induced in cultured fetal astrocytes. In particular, IFN-gamma induced the highest levels of TRAIL in cultured astrocytes. When astrocytes were pre-treated with IFN-gamma, they induced apoptosis in TRAIL-sensitive Peer cells. Our results suggest that IFN-gamma modulates the expression of TRAIL in astrocytes, which may enhance cytotoxic sensitivity of infiltrating immune cells or brain cells other than astrocytes during inflammation of brain.
研究了原发性人脑海马星形胶质细胞中肿瘤坏死因子相关凋亡诱导配体（TRAIL）在促炎细胞因子作用下的表达情况。当星形胶质细胞用白细胞介素-1β、肿瘤坏死因子-α或干扰素-γ处理时，培养的胎儿星形胶质细胞中会诱导产生TRAIL。特别是，干扰素-γ在培养的星形胶质细胞中诱导产生的TRAIL水平最高。当星形胶质细胞用干扰素-γ预处理后，它们会诱导TRAIL敏感的Peer细胞发生凋亡。我们的结果表明，干扰素-γ调节星形胶质细胞中TRAIL的表达，这可能会增强脑部炎症期间浸润的免疫细胞或除星形胶质细胞以外的脑细胞的细胞毒性敏感性。
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