Zeng Fanlong, Yu Zhengkun
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning 116023, People's Republic of China.
J Org Chem. 2006 Jul 7;71(14):5274-81. doi: 10.1021/jo060795d.
Palladium complexes of two new types of unsymmetrical pyridyl-supported pyrazolyl-N-heterocyclic carbene ligands were synthesized and structurally characterized. A strategy to release the steric strain of the ligand was realized by the introduction of methylene linkers to the ligand molecule. All the palladium complexes exhibited good to excellent catalytic activity in Suzuki-Miyaura reactions of phenyl or p-tolylboronic acid with aryl halides including iodobenzene, aryl bromides, and activated aryl chlorides under mild conditions, revealing that the new ligands are promising for the construction of highly active transition-metal catalysts.
合成并对两种新型不对称吡啶基支载的吡唑基 - N - 杂环卡宾配体的钯配合物进行了结构表征。通过在配体分子中引入亚甲基连接基团实现了释放配体空间张力的策略。所有钯配合物在温和条件下对苯基硼酸或对甲苯基硼酸与芳基卤化物（包括碘苯、芳基溴化物和活性芳基氯化物）的铃木 - 宫浦反应中均表现出良好至优异的催化活性，这表明新配体在构建高活性过渡金属催化剂方面具有潜力。
